Sponsor: N/A
Objective: This study aims to examine the effect of a brief, written self-compassion intervention on cognitive (cost and likelihood biases, post-event processing) and physiological (HF-HRV, salivary alpha-amylase) mechanisms underlying social anxiety, with the goal of clarifying the pathways through which self-compassion may alleviate social anxiety symptoms.
Clinical Trials Registry: N/A
Status:  This study is currently recruiting participants.
IRB Protocol: 0007836

Sponsor: Clara Mayo Memorial Fellowship
Objective: This study aims to explore the predictive significance of relative neurocognitive impairments on extinction learning in the context of exposure-based therapy for anxiety disorders. Participants will be directly recruited from the ongoing larger clinical trial conducted at UT and Boston University, CO₂ Reactivity as a Biomarker of Non-response to Exposure-based Therapy, and will be asked to complete a neurocognitive assessment battery prior to (or during the initial weeks of) engaging in that 12-week open exposure-based treatment (that is, study participation as usual). Diagnostic, symptom severity, CO2 reactivity data, and treatment outcome variables will be taken (as per consent form) from the larger study.
Clinical Trials Registry: N/A
Status:  This study is currently recruiting participants.
IRB Protocol: 6632E

Sponsor: Congressionally Directed Medical Research Programs Traumatic Brain Injury and Psychological Health Research Program sponsored by the Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense
Objective: The objectives of this study are to provide continued safety assessment for the ReStore system, and to gain further estimates of the effect size of Vagus Nerve Stimulation therapy with Prolonged Exposure Therapy (PE) compared to PE with placebo (sham) stimulation in participants with posttraumatic stress disorder.
Clinical Trials Registry: Click here.
Status:  This study is currently recruiting participants.
IRB Protocol: 00005066

Sponsor: National Institute of Mental Health
Objective: Cognitive behavior therapy (CBT) is an effective treatment for anxiety and fear-related disorders. However, some patients fail to achieve complete remission or show a return of anxiety symptoms following treatment. The purpose of the study is to determine the extent to which one’s emotional reaction to a CO₂ inhalation task can help predict who might or might not respond to therapy. If CO₂ reactivity proves to be successful in predicting who will benefit from CBT versus who will not, clinicians can make better decisions about which patients should be treated with CBT.
Clinical Trials Registry: Click here.
Status: This study is currently recruiting participants.
IRB Protocol: 2016-09-0150

Grant Awarded: April 27, 2022

Sponsor: National Cancer Institute
Objective: Cigarette smoking is the leading cause of preventable death in the United States, contributing to over 480,000 deaths each year or about 1 of every 5 deaths. Though approximately 70% of current adult smokers are motivated to quit, and significant strides have been made in the development of effective smoking cessation treatments, most established interventions are associated with relatively low long-term abstinence rates (15-35%). The purpose of the study is to determine the efficacy of an aerobic exercise-based smoking cessation intervention in people with high anxiety sensitivity. Participants will be assigned a personal trainer at the YMCA to assist with intervention adherence, receive Nicotine Replacement Therapy in the form of patches, and counseling through the Texas Tobacco Quitline.
Clinical Trials Registry: Click here.
Status: This study is currently recruiting participants.
IRB Protocol: 2016-12-0049

Grant Awarded: July 23, 2023

Sponsor: Cancer Prevention and Research Institute of Texas
Objective: Cigarette smoking is the leading cause of death and disability in the United States. People with psychiatric disorders consume almost half (44.3%) of all cigarettes smoked in the U.S. Effective quit-smoking treatments for people with psychiatric disorders are sorely needed. Our aims in the current project are to develop and test an iPad tablet, motivational counseling intervention that does not require a trained professional counselor. Our goal is to conduct a clinical study to evaluate the effectiveness of this iPad-based, Sustained Care intervention for smokers engaged in psychiatric hospitalization, by comparing it to the brief advice to quit smoking that is part of usual hospital care. Those who receive the iPad intervention will also be provided with quit-smoking resources (Texas Tobacco Quitline referral and nicotine patches) upon hospital discharge.
Status: This study is currently recruiting participants.
IRB Protocol: 00002552

Grant Awarded: February 16, 2022